Jump to main content Jump to site nav Home Here’s a 2D version of the structure, for easier comprehension. The Waste Framework Directive aims to protect the environment and human health from the generation and management of waste and to improve efficient use of resources. For a detailed overview on identified uses and environmental releases, please consult the registered substance factsheet. It is also known as phosphoric(V) acid or orthophosphoric acid. ECHA has no public registered data indicating whether or in which chemical products the substance might be used. Molecular Formula: H3O2P.1/2Ni Additional Metadata. A substance identified primarily by an EC or list number may be linked with more than one CAS number, or with CAS numbers that have been deleted. To H-phosphinic acid or H-phosphinic acid ethyl ester (5.0 mmol, 1.0 equiv.) REACH regulation aims to improve the protection of human health and the environment from the risks that can be posed by chemicals. The information is aggregated from the data coming from REACH substance registrations provided by industry. CopyCopied, CSID:21100, http://www.chemspider.com/Chemical-Structure.21100.html (accessed 14:34, Dec 8, 2020) About Us; Covid; Our Services. In that case, the ATP (Adaptation to Technical Progress) number is displayed. Please note: Precautionary measures and guidance on safe use concern the use and handling of the specific substance as such, not of the presence of the substance in other articles or mixtures. The REACH registered substance data and the C&L Inventory portal will be upgraded from the 9th November. It is present in teeth and bone and helps in metabolic processes. The examples provided are generic examples and may not apply to the specific substance you are viewing. Such notifications are required for hazardous substances, mixtures, or articles, manufactured or imported at over 1 kg per annum. Direct methods that make use of phosphorous acid (H 3 PO 3 ) and that produce a phosphonic acid functional group simultaneously to the formation of the P–C bond, are also surveyed. The ‘Substance identity’ section is calculated from substance identification information from all ECHA databases. It is … 52849-30-6. This substance has an industrial use resulting in manufacture of another substance (use of intermediates). Hypophosphorous acid (HPA), or phosphinic acid, is a phosphorus oxyacid and a powerful reducing agent with molecular formula H3PO2. The molecular structure is based on structures generated from information available in ECHA’s databases. Use this link for bookmarking this species for future reference. The single-bonded oxygen atoms are bunched much closer to each other than any of them is to the double-bonded oxygen atom. REACH registration dossiers have greater data requirements (such as supporting studies) than do notifications under CLP. The precautionary measures and guidance on safe use are as submitted to ECHA by registrants under the REACH Regulation. The oxygen atoms with a single bond are further connected to one hydrogen atom each, thus satisfying their valency. The quality and correctness of the information submitted to ECHA remains the responsibility of the data submitter. Welcome to the ECHA website. The CLP Regulation uses the UN Global Harmonised System (GHS) and European Union Specific Hazard Statements (EUH). API Catalogue; Data Intelligence Phosphinic acid derivatives (also identified as phosphonous acid) are prepared by reaction of hypophosphorous acid on alkene or alkyne (hydrophosphonation) , by its addition on aldehyde or imine or by hydrolysis of alkyl or aryldichlorophosphine (RPCl 2) (for a review see reference ). The 3D structure of phosphoric acid is given below. Other names: Diphenylphosphinic acid; Hydroxydiphenylphosphine oxide; P,P-diphenylphosphinic acid Permanent link for this species. The ‘Hazard classification and labelling’ section shows the hazards of a substance based on the standardised system of statements and pictograms established under the CLP (Classification Labelling and Packaging) Regulation. Print infocard. If generated, an InChI string will also be generated and made available for searching. Phosphoric Acid is an acid-containing four atoms of oxygen, one atom of phosphorus, and three atoms of hydrogen. Other relevant information includes the following: To see the full list of notified classifications and to get more information on impurities and additives relevant to classification please consult the C&L Inventory. Harmonisation is based on the substance’s physical, toxicological and eco-toxicological hazard assessment. The molecular formula identifies each type of element by its chemical symbol and identifies the number of atoms of each element found in one discrete molecule of the substance. The Support section provides tools and practical guidance to companies which have responsibilities under the EU chemicals legislation. The InfoCard summarises the non-confidential data of a substance held in the databases of the European Chemicals Agency (ECHA). The purpose of the information provided under this section is to highlight the substance hazardousness in a readable format. phosphinic acid: ChEBI ID CHEBI:29031: Definition A phosphorus oxoacid that consists of a single pentavalent phosphorus covalently bound via single bonds to two hydrogens and a hydroxy group and via a double bond to an oxygen. In its liquid form, it appears as a clear, colorless solution and in its solid form, it appears as transparent, crystalline solid. The molecular structure of the hydrogen bonded cyclic dimer of dimethylphosphinic acid was studied by gas-phase electron diffraction at 433K. The CLP Regulation makes sure that the hazards presented by chemicals are clearly communicated to workers and consumers in the European Union. The molecular structure is based on structures generated from information available in ECHA’s databases. Although this chemical structure contains three hydrogen atoms, it is a diprotic acid. Additionally, if available, information on the use of the substance and how consumers and workers are likely to be exposed to it can also be displayed here. 2074-67-1 - INZLXIUOICFWDW-UHFFFAOYSA-N - Bis(hydroxymethyl)phosphinic acid - Similar structures search, synonyms, formulas, resource links, and other chemical information. Substances indicated, in 2009, as being intended to be registered by at least one company in the EEA. However, substance notifications in the InfoCard are aggregated independently of the impurities and additives. This information is only displayed if the substance is well–defined, its identity is not claimed confidential and there is sufficient information available in ECHA’s databases for ECHA’s algorithms to generate a molecular structure. The fluoroaryl phosphinic acid undergoes reversible P–H addition to the carbonyl functionality of ketones under formation of a P–C bond which is retained in the resulting α-hydroxy phosphinic acid. This substance is used in the following products: pH regulators and water treatment products, coating products, fillers, putties, plasters, modelling clay, finger paints, metal surface treatment products, non-metal-surface treatment products, laboratory chemicals, polymers, washing & cleaning products, water treatment chemicals and welding & soldering products. As a sequestering agent, it helps in the binding of divalent cations. Salts derived from this acid are called hypophosphites. It does not represent a new labelling, classification or hazard statement, neither reflect other factors that affect the susceptibility of the effects described, such as duration of exposure or substance concentration (e.g. ... Molecular structure. This section provides links to the list of precautions (precautionary statements) and to the guidance on safe use, if they have been provided in REACH registration dossiers. Copyright © 2016-2018 W. Robien, Inst. The per substance REACH registration status will be made available as soon as possible thereafter. Comment (2-Carboxyethyl)(phenyl)phosphinic acid (H 2 L) is a flame-retardant additive for polymers such as polyesters (Levchik & Weil, 2005). inside a watch) or with very low concentrations considered not to pose risks to human health or the environment. Union List of Authorized Substances: Annex I, Plastics Food Contact Regulation 10/2011/EU, as amended by Regulation 2020/1245/EU, 3 September 2020, Registration, Evaluation, Authorisation and Restriction of Chemicals, Chemical Agents Directive and Carcinogens or Mutagens Directive, Plastic Materials and Articles Regulation, FCM and Articles Regulation, Annex I - Authorised Substances, EC Inventory, C&L Inventory, Registration dossier, Pre-Registration process, Other, FCM and Articles Regulation, Annex I - Authorised Substances, Substances of very high concern identification, Recommendation for the Authorisation List, Getting started with EU chemicals legislation, Classification of substances and mixtures, Harmonised classification and labelling (CLH). C&L Inventory . Use descriptors are adapted from ECHA guidance to improve readability and may not correspond textually to descriptor codes described in Chapter R.12: Use Descriptor system of ECHA Guidance on information requirements and chemical safety assessment. ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment. Unexpected carbon–sulfur bond formation took place in the reaction between phosphinic acid thioesters and benzyl Grignard reagents. Release to the environment of this substance can occur from industrial use: in processing aids at industrial sites, as processing aid, as an intermediate step in further manufacturing of another substance (use of intermediates) and in the production of articles. Product Identification Synonyms: Orthophosphorous acid CAS No. Phosphinic acid, nickel(2+) salt (2:1) CAS Number: 14507-36-9. in case of consumer and professional uses). Substances which have been registered and can be placed on the EEA market by those companies with a valid registration. This section provides an overview of the calculated volume at which the substance is manufactured or imported to the European Economic Area (EU28 + Iceland, Liechtenstein and Norway). Information on applicable regulatory frameworks is also automatically generated and may not be complete or up to date. An ambident electrophilicity of phosphinic acid thioesters is disclosed. C&L Inventory, Registration dossier . ... phosphinic acid . Phosphonic acid 1. Please upgrade your Internet Explorer to a newer version. InfoCards are updated when new information is available. The phosphorus atom in a phosphoric acid molecule is bonded with 4 oxygen atoms, one with a double bond and the other three with single bonds. … Here you can find all of the regulations and regulatory lists in which this substance appears, according to the data available to ECHA. It is the responsibility of the substance manufacturers and importers to consult official publications, e.g. BPR regulation aims to improve the functioning of the biocidal products market in the EU, while ensuring a high level of protection for humans and the environment. Danger! When information is available in all sources, the first two are displayed as a priority. Orthophosphoric acid has only one strongly ionizing proton, with a pK1 of 2.1. Phosphinic acid, P,P-bis(2,4,4-trimethylpentyl)- Valid: 01/20/2010: Active 2020 CDR TSCA Inv Active Phosphinic acid, P,P-bis(2,4,4-trimethylpentyl)- Unknown: Active TSCA Inv Phosphinic acid, P,P-bis(2,4,4-trimethylpentyl)- Valid: Active Media in category "Phosphinic acids" The following 15 files are in this category, out of 15 total. It is possible that a harmonisation is introduced through an amendment to the CLP Regulation. More information about Classification and Labelling is available in the Regulations section of ECHA website. Release to the environment of this substance can occur from industrial use: formulation of mixtures. Release to the environment of this substance can occur from industrial use: manufacturing of the substance. 4 Spectral Information. : 13598-36-2 Molecular Weight: 82.00 Chemical Formula: H3PO3 Urgent contact: Shanghai Sunivo Supply Chain Management Co., Ltd. Tel: +86 21 3393 3299 Fax: +86 21 5830 7878 URL: www.sunivo.com Address: Room 502, Building 5, Lane 289 Bisheng Rd., Pudong District, The POPs Regulation bans or severely restricts the production and use of persistent organic pollutants in the European Union. The EC Inventory is a combination of three independent European lists of substances from the previous EU chemicals regulatory frameworks (EINECS, ELINCS and the NLP-list). If a substance is classified under multiple CLH entries, a link to the C&L Inventory is provided to allow users to view CLH information associated with the substance and no text is automatically generated for the InfoCard. Phospinic Acid . Besides de novo synthesis, PA can be formed in three ways: By phospholipase D (PLD), via the hydrolysis of the P-O bond of phosphatidylcholine (PC) to produce PA and choline. Synthesis, Crystal Structures, and Solution Properties ofN-Methylene(phenyl)phosphinic Acid Derivatives of Cyclen and Cyclam Preparation of phosphonic acid by oxidation of phosphinic acid. ECHA maintains the C&L Inventory, but does not review or verify the accuracy of the information. the products in which the substance may be used) may refer to uses as intermediate and under controlled conditions, for which there is no consumer exposure. These notifications can be provided by manufacturers, importers and downstream users. Structure, properties, spectra, suppliers and links for: Hypophosphorous acid, 6303-21-5, H2PO(OH), PH2(OH)O, PH2O(OH). CopyCopied, Validated by Experts, Validated by Users, Non-Validated, Removed by Users, Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, Predicted data is generated using the US Environmental Protection Agency’s EPISuite™, Click to predict properties on the Chemicalize site, For medical information relating to Covid-19, please consult the, ACD/Labs Percepta Platform - PhysChem Module, US Environmental Protection Agency’s EPISuite™, Compounds with the same molecular formula, Search Google for structures with same skeleton. More information about CAS and the CAS registry can be found here. The described Product category (i.e. Likewise the per substance indication of harmonised C&L, Seveso directive, or notified C&L regulatory context will be made available as soon as possible. Phosphorous acid is an acid containing phosphorous and the chemical formula is H 3 PO 3. Lehrstuhl für Anorganische Chemie II, Technische Universität Dortmund, Otto‐Hahn‐Straße 6, … Michael Lutter. and boron trifluoride diethyl ether (0.13 or 0.31 mL, 1.0 or 2.5 mmol, 0.2 or 0.5 equiv.) The CLP Regulation ensures that the hazards presented by chemicals are clearly communicated to workers and consumers in the European Union through classification and labelling of chemicals. Structure incompatible with current estimation method! nodiamide, or by oxidation of phosphinic acid. Substances listed in the EINECS, ELINCS, or NLP inventories. The Prior Informed Consent Regulation administers the import and export of certain hazardous chemicals and places obligations on companies who wish to export these chemicals to non-EU countries. CopyCopied, GQZXNSPRSGFJLY-UHFFFAOYSA-N phosphorus dioxide. ECHA has no public registered data indicating whether or in which chemical products the substance might be used. The report also explains in-depth details of shifting market dynamics, pricing structures, market trends, restraints, limitations, demand-supply variations, growth-boosting factors, and market variations that have been considered the most important factors in the carboxyethyl phenyl phosphinic acid … It covers their hazardous properties, classification and labelling, and information on how to use them safely. Precautionary statements - describe recommended measures to minimise or prevent adverse effects resulting from exposure to a hazardous product or improper storage or handling of a hazardous product. Chemical structure: This structure is also available as a 2d Mol file or as a computed 3d SD file The 3d structure may be viewed using Java or Javascript. Molecular structure. Haruo Seto, in Comprehensive Natural Products Chemistry, 1999. C&L Inventory . The substance identifiers displayed in the InfoCard are the best available substance name, EC number, CAS number and/or the molecular and structural formulas. 215–540–4, is covered by three harmonisations: 005–011–00–4; 005–011–01–1 and 005–011–02–9), CLH information cannot be displayed in the InfoCard as the difference between the CLH classifications requires manual interpretation or verification. were added triethyl orthoacetate (5.5 mL, 30.0 mmol, 6.0 equiv.) Harmonised classification and labelling is a legally binding classification and labelling for a substance, agreed at European Community level. The CAS number is the substance numerical identifier assigned by the Chemical Abstracts Service, a division of the American Chemical Society, to substances registered in the CAS registry database. Unterphosphorige Säure . Occupational exposure limit (OEL) values are derived within two legal frameworks that form an integral part of the EU’s mechanism for protecting the health of workers. If no EU harmonised classification and labelling exists and the substance was not registered under REACH, information derived from classification and labelling (C&L) notifications to ECHA under CLP Regulation is displayed under this section. Trade names . phosphinic acid moieties. InChI=1S/C7H8NO2P/c8-7 (11 (9)10)6-4-2-1-3-5-6/h1-5,7H,8H2/p+1 … Sorption to aerosols (25 Dec C)[AEROWIN v1.00]: Vapor pressure (liquid/subcooled): 1.01E-007 Pa (7.58E-010 mm Hg) Log Koa (Koawin est ): 3.538 Kp (particle/gas partition coef. Packaging … The second proton, with a pK of 7.2, is not more acidic than those of water. Information on precautionary measures and the safe use is submitted by the registrant of a substance and the registrant is solely responsible for its accuracy and completeness. According to the classification provided by companies to ECHA in REACH registrations this substance causes severe skin burns and eye damage, causes serious eye damage and may be corrosive to metals. 1707-03-5 - BEQVQKJCLJBTKZ-UHFFFAOYSA-N - Phosphinic acid, diphenyl- - Similar structures search, synonyms, formulas, resource links, and other chemical information. Please note that it may take a week or two to have everything fully in place, and please be aware in the meantime that the Registration status may be incorrect and the CLP regulatory context may be incompletely shown. ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment. This substance is used in the following areas: formulation of mixtures and/or re-packaging. The EC Number is the numerical identifier for substances in the EC Inventory. The ‘Hazard classification’ and labelling section uses the signal word, pictogram(s) and hazard statements of the substance under the harmonised classification and labelling (CLH) as its primary source of information. This substance is used for the manufacture of: chemicals and plastic products. InfoCards are generated automatically based on the data available at the time of generation. The parent of the class of phosphinic acids. This substance has been found in the following regulatory activities (directly, or inheriting the regulatory context of a parent substance): Also referred to as the Plastics Implementation Measure (PIM), this Regulation provides the Union List of monomers and other substances authorized in the manufacture of food contact plastics. Furthermore, some substances can be found in an article, but with unlikely exposure (e.g. Substances for which classification and labelling data have been notified to ECHA by manufacturers or importers. In water, the dissociation of the phosphoric acid and the release of the protons follow the equilibria shown in Figure 6. This substance is used in the following products: coating products, fillers, putties, plasters, modelling clay, finger paints, metal surface treatment products, non-metal-surface treatment products, pH regulators and water treatment products, laboratory chemicals, washing & cleaning products, water treatment chemicals and welding & soldering products. Chem., Univ. This information is only displayed if the substance is well-defined, its identity is not claimed confidential and there is sufficient information available in ECHA’s databases for ECHA’s algorithms to generate a molecular structure. Guidance on safe use - recommendations by substance registrant on the proper use of the substance in various situations. This website uses cookies to ensure you get the best experience on our websites. For readability purpose, only non-confidential use descriptors occurring in more than 5% of total occurrences are displayed. Some substance identifiers may have been claimed confidential, or may not have been provided, and therefore not be displayed. of Org. What is the Classification and Labelling Inventory? This information has not been reviewed or verified by ECHA, and may change without prior notice. The synthesis, structure and reactivity of the fluoroaryl phosphinic acid HF 4 C 6 –P(O)HOH is reported and compared to a sterically comparable yet non-fluorinated analog with similar size. A substance may have its use restricted to certain articles or products and therefore not all the examples may apply to the specific substance. 71-75 Shelton Street, London, WC2H 9JQ United Kingdom. Close Find out more on how we use cookies. The EC or list number is the primary substance identifier used by ECHA. This site is not fully supported in Internet Explorer 7 (and earlier versions). ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment. 1.30.2.3.2 Formation of phosphonoformic acid, a substrate for the phosphinic acid formation reaction. the electronic edition of the Official Journal of the European Union. This project is supported by The Metabolomics Innovation Centre (TMIC), a nationally-funded research and core facility that supports a wide range of cutting-edge metabolomic studies.TMIC is funded by Genome Alberta, Genome British Columbia, and Genome Canada, a not-for-profit organization that is leading Canada's national genomics strategy with $900 million in funding from the federal government. This section is based on three sources for information (harmonised classification and labelling (CLH), REACH registrations and CLP notifications). Note that for readability purposes, only the pictograms, signal words and hazard statements referred in more than 5% of the notifications under CLP are displayed. The source of the information is mentioned in the introductory sentence of the hazard statements. The date of the last update corresponds to the publication date of the InfoCard and not necessarily to the date in which the update occurred in the source data. Aryl(dimethylaminomethyl)phosphinic Acid Esters: Syntheses, Structures, and Reactions with Halogen Hydrogen Acids, Tin Halides, and Trimethyl Halosilanes. Bis (2,4,4-trimethylpentyl)-phosphinic acid, or so-called Cyanex 272, is produced by Cytec to separate Ni and Co. By comparison of HEH (EHP) and HDEHP, Cyanex 272, the structure shown below, contains two alkyl groups attached to the phosphorus atom. A diprotic acid is an acid that is capable of releasing two hydrogen ions (protons) to an aqueous medium. This substance has not been registered under the REACH Regulation, therefore as yet ECHA has not received any data about this substance from registration dossiers. disodium tetraborate EC no. This is unique source of information on the chemicals manufactured and imported in Europe. 2 Names and Identifiers. The developed method for benzyl sulfides has a wide substrate scope and … ECHA organises consultations to get feedback from all interested parties and to gather the widest possible range of scientific information for the regulatory processes. Hazard statements were adapted to improve readability and may not correspond textually to the hazard statements codes description in the European Union Specific Hazard Statements (EUH) or the. If the substance was not covered by the EC Inventory, ECHA attributes a list number in the same format, starting with the numbers 6, 7, 8 or 9. Its related homologue, (carboxymethyl)(phen-yl)phosphinic acid, has also been investigated for the construction of metal–organic frameworks (Midollini et al., 2005). InChI=1S/HO2P/c1-3-2/h(H,1,2) Please be aware there may be intermittent unavailability while work in ongoing. The use information is displayed per substance life cycle stage (consumer use, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites or in manufacturing). If at least one company has indicated that the substance classification is affected by impurities or additives, this will be indicated by an informative sentence. If available, additional information on classification and labelling (C&L) is derived from REACH registration dossiers submitted by industry. The formula for this acid is generally written H3PO2, but a more descriptive presentation is HOP(O)H2, which highlights its monoprotic character. ​ic acid | \ (ˈ)fä¦sfinik- \ Definition of phosphinic acid : any of a series of monobasic organic acids RR′PO (OH) [as diphenyl-phosphinic acid (C6H5)2PO (OH)] obtainable from disubstituted phosphines by oxidation — compare phosphonic acid EU. ECHA has no public registered data indicating whether or into which articles the substance might have been processed. Examples include recommended measures on fire-fighting, transport and recycling and disposal. Substances may have impurities and additives that lead to different classifications. Biocidal Products Committee opinions on active substance approval, National authorisation and mutual recognition, Understanding the Waste Framework Directive, Tools to prepare and submit SCIP notifications, List of substances subject to the POPs Regulation, Draft recommendation for inclusion in the Authorisation List and consultation, Submitted restrictions under consideration, Harmonised classification and labelling targeted consultations, Consultations on ECHA Executive Director’s requests, PACT - Public Activities Coordination Tool, Information on Candidate List substances in articles, Candidate List of substances of very high concern for Authorisation, Registry of restriction intentions until outcome, Registry of SVHC intentions until outcome, Table of harmonised entries in Annex VI to CLP, Occupational exposure limits - Activity list, Harmonised classification and labelling (RAC), Chapter R.12: Use Descriptor system of ECHA Guidance on information requirements and chemical safety assessment, Guidance on the safe use of the substance, Previous consultations on ECHA’s Executive Director Requests to the Committees, Applications for authorisation consultations, Harmonised classification and labelling consultations, ECHA Executive Director’s requests related to the CLH process, Consultation on potential candidates for substitution, Consultation on derogation to the exclusion criteria, ECHA's Executive Director Requests to the Committees, Consultation on a draft recommendation for amendment of Authorisation List entries, Consultations in the authorisation process, Occupational exposure limits - Call for comments and evidence, Occupational exposure limits - Previous calls for comments and evidence, Occupational exposure limits – Consultations on OEL recommendation, Derogations for the protection of cultural heritage, ECHA's current activities on restrictions, ECHA's completed activities on restriction, Information on Candidate List substances in articles table, Information from the Existing Substances Regulation (ESR), PBT/vPvB assessments under the previous EU chemicals legislation, Adopted opinions and previous consultations on applications for authorisation, Adopted opinions on restriction proposals, Mapping exercise – Plastic additives initiative, Occupational exposure limits substance evaluations, List of substances subject to POPs Regulation, Small and Medium-sized Enterprises (SMEs), Practical examples of chemical safety reports.

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